Ecuador Confirms Third Yellow Fever Case in 2025

The Yellow fever outbreak in South America now includes the Republic of Ecuador, home to approximately 17 million residents.

As of April 28, 2025, Ecuador's Public Health Minister, Edgar Lama, announced that there are three confirmed cases, with a fourth case under investigation.

The first case was detected in the province of Zamora Chinchipe, located at the southeastern end of the Amazon Basin. 

Furthermore, Minister Lama stated in a media release, "We remain vigilant and are not in any situation similar to Colombia and Peru, which have had so many cases of yellow fever," he stated.

As of the end of April 2025, yellow fever outbreaks have been reported throughout South America.

Ecuador is a popular tourist destination that features the Galápagos Islands in the Pacific Ocean.

To alert international travelers to the Yellow fever health risk, the U.S. CDC states that proof of vaccination is not required for direct travel from the United States, or when traveling to areas above 7,550 ft in elevation, or the cities of Guayaquil or Quito, or the Galápagos Islands.

However, the CDC has included Ecuador in recent Dengue and Oropouche in Level 1 Travel Health Advisories.

In the United States, yellow fever vaccination appointments are offered at certified travel clinics and pharmacies.